25B-NBOH

Description

Overview

25B-NBOH 1.2mg Blotters

25B-NBOH 1.2mg Blotters (also known as 2C-B-NBOH and NBOH-2C-B) is novel synthetic psychedelic substance of the phenethylamine chemical class  It is a closely related analog of 25B-NBOMe and is reported to share most of its properties

The name 25B-NBOH, which is short-hand for 2C-B-NBOH, is a derivative of the phenethylamine psychedelic 2C-B. It was first synthesized and documented in 2011 by Martin Hansen at the University of Copenhagen.

Chemistry

25B-NBOH or 2C-B-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-B. 25B-NBOH is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as an bromine atom attached to carbon R4. It differs from 2C-B structurally through a substitution on the amine (NH2) with a 2-hydroxybenzyl (BOH) group. 25B-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R2. Learn More

25B-NBOH 1.2mg Blotters Pharmacology

25B-NBOH has efficacy at the 5-HT2A receptor where it acts as a potent agonist.

This compound is pharmacologically unique when compared to other psychedelics due to the unusually high selectivity it displays for various serotonin receptors. It is notable as one of the most selective agonist ligands for the 5-HT2A receptor with a pEC50 value of 9.87 nMIt has a pKi of 0.061 nM at the human 5HT2A receptor, similar to the better-known compound 25B-NBOMe.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. learn more